Endocrine Abstracts

Background: Although it accounts for small number (1–2%) of diabetes cases, MODY is especially important to be picked up by health care providers because of the implications of the correct diagnosis on clinical management and family counselling. MODY should be suspected when a patient <25 years old presents with symptoms of diabetes, who has a family history of diabetes/ MODY, with negative diabetes autoantibodies screen, and/or suboptimal response to...

Introduction: Gastroparesis is one of the dysautonomic manifestations of diabetic disease, particularly type 1. Often unnoticed or undetected by the clinician, it can be at the heart of a permanent imbalance, giving rise to all the microvascular and macrovascular complications of dysglycemia. We report the case of a diabetic patient who, after diagnosis and treatment of gastroparesis, achieved spectacular glycemic control.Observation: This is a 20-year-o...

Introduction: Hereditary hemochromatosis is a common disorder in white population with a prevalence of 4-6.4%. It is a systemic disorder that affects multiple organs. It could affect the pituitary gland leading to hypogonadotropic hypogonadism and could affect other pituitary hormones to a lesser extent. We present a rare case of hereditary hemochromatosis leading to hypotension most likely due to iron infiltration of the pituitary gland.Case presentatio...

DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 [1-3] as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome, usually presents later in childhood, often leading to hypernasal speech caused by cleft palate, submucous cleft palate, or velopharyngeal insufficiency. Both disorders share similar clinical feature...

Introduction: DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome.Case report: A 17-year-old Moroccan male was mildly mentally challenged and had seizures from the age of 9 years. He had dysmorphic facial features, and mild tortuosity...

Introduction: Parathyroid adenoma can be localized in an ectopic situation, especially at the mediastinal level. The localization at the level of the RLN chain lymph node has not been reported yet.Case presentation: A 67-year-old woman without clinical signs of hyperparathyroidism, having undergone a left isthmolobectomy for a thyroid nodule suspected of being malignant, with intraoperative discovery of lymphadenopathy of the left RLN chain lymph node. T...

Introduction: Most pituitary adenomas are benign. However, there are invasive forms with rapid growth rate and particular histological signs (atypical adenomas), making them considered pituitary carcinomas without metastases.Observation: A 63-year-old patient was followed for 10 years for Cushing’s disease in the pituitary macrodenoma. Clinical evaluation found Cushing syndrome, pituitary tumor syndrome associated with diplopia, and trigeminal neura...

Introduction: There are emerging reports showing the relationship between human immunodeficiency virus (HIV), Covid-19 and adrenal insufficiency. This was attributed to thrombotic events and necrosis, leading to hypoadrenalism. The HIV virus can also lead to Addison”s disease due to destruction of adrenal gland. Prevalence of adrenal infarction with COVID-19 was found to be 23% and 88% this was shown to be affecting both adrenal glands. Case report:...

Introduction: Primary hyperparathyroidism is associated with lithiasis, but this has been universally considered to refer to kidney lithiasis. Sialolithiasis as a comorbidity or result of primary hyperparathyroidism is uncommon. We report a rare case of submandibular lithiasis in a child and discuss the etiological assessment of this condition.Materials and Methods: We report a rare case of submandibular lithiasis in a child revealing primary hyperparath...

Introduction: Primary hyperparathyroidism is a frequent pathology, its association with papillary thyroid carcinoma is rare.Case Report: A 53 year old patient was admitted for management of primary hyperparathyroidism. The biological work-up showed a blood calcium level of 120 mg/l, parathyroid hormone (PTH) 4 times the normal range and hypophosphatemia. Cervical ultrasound showed a right parathyroid nodule with thyroid nodules classified Tirads 4, MIBI ...